中文版
Signaling Pathways
Evofosfamide
Catalog No. :
CL2636
Product Name :
Evofosfamide
CAS No. :
918633-87-1
Synonyms :
TH-302
Chemical Name :
Molecular Formula :
C9H16Br2N5O4P
Molecular Weight :
449.04
Molecular Structure :
Appearance :
White to yellow powder
Specification :
98+%
Application :
Registration :
Storage Condition :

Evofosfamide (TH-302) is potent and selective that has an IC50 of 19 nM. It exhibits 270-fold increased cytotoxicity under hypoxia compared to their potency under aerobic conditions and is stable to cytochrome P450 metabolism. Under hypoxia, TH-302 is selectively potent and liver microsomes tolerate it well. With a high hypoxic selectivity [Hypoxia cytotoxicity ratio (HCR) = 270], replacing the chlorine with bromine in the phosphorus mustard in 3b results in a 10-fold increase in potency. Under N2, TH-302 exhibits strong cytotoxicity against human lung cancer H460 cells and human colon cancer HT29 cells. With an IC90 of 0.1 μM and 0.2 μM, respectively, TH-302 inhibits HT29 cells and H460 cells.

Statement:
->>Products covered by valid patents are not offered or supplied for commercial use.
->>Products currently covered by valid US Patents are offered for laboratory R&D use in accordance with 35 USC 271(e)+A13(1).
->>Any patent infringement and resulting liability is solely at buyer's risk.
->>Our products are only raw materials for drugs or industry, can't be used for human or animals directly.

Request A Quote
Your Name(required)
Email(required)
Product Name(required)
Country or Region(required)
Organization Name(required)
Messages(required)
Captcha(required)
Sending...