Catalog No. :	CL2830
Product Name :	GNE-9815
CAS No. :	2729996-45-4
Synonyms :
Chemical Name :
Molecular Formula :	C26H22FN5O2
Molecular Weight :	455.48
Molecular Structure :
Appearance :	Off-white to light yellow powder
Specification :	98+%
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GNE-9815 (compound 7) is a highly selective, orally bioavailable pan-RAF inhibitor. For CRAF and BRAF, respectively, GNE-9815 displays Ki values of 0.062 and 0.19 nM. The MAPK pathway is modulated synergistically when GNE-9815 and the MEK inhibitor Cobimetinib are combined. Cancers with the KRAS mutation can be studied using GNE-9815.

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