Catalog No. :	HL1018
Product Name :	Celastrol
CAS No. :	34157-83-0
Synonyms :	Tripterin | Tripterine
Chemical Name :	3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Molecular Formula :	C29H38O4
Molecular Weight :	450.61
Molecular Structure :
Appearance :	Red crystal powder
Specification :	98+%
Application :	A proteasome inhibitor, has anti-cancer and anti-inflammatory properties
Registration :
Storage Condition :	Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.

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