Catalog No. :	CL1106
Product Name :	Nemorubicin
CAS No. :	108852-90-0
Synonyms :	Methoxymorpholinyldoxorubicin | PNU 152243 | PNU-152243A | | DMM Dox | MMRDX | FCE 23762 | PNU 152243
Chemical Name :	(8S,10S)-6,8,11-trihydroxy-10-(((2R,4S,5S,6S)-5-hydroxy-4-((S)-2-methoxymorpholino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione.
Molecular Formula :	C32H37NO13
Molecular Weight :	643.64
Molecular Structure :
Appearance :	Orange to reddish brown powder
Specification :	98+%
Application :	antitumor activity
Registration :
Storage Condition :	4°C, protect from light

Nemorubicin (Methoxymorpholinyl doxorubicin) is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .

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