Catalog No. :	CL2485
Product Name :	PD184352(CI-1040)
CAS No. :	212631-79-3
Synonyms :	CI-1040
Chemical Name :
Molecular Formula :	C17H14ClF2IN2O2
Molecular Weight :	478.66
Molecular Structure :
Appearance :	White to off-white powder
Specification :	98+%
Application :
Registration :
Storage Condition :

PD184352 (PD-184352; CI-1040), an analog of benzhydroxamate, is an orally bioactive, specific, allosteric/non-ATP competitive MEK1/2 inhibitor with potential anticancer activity. In cell-based assays, it inhibits MEK1/2 with IC50 values of 17 nM and exhibits a 100-fold preference for MEK1/2 over MEK5. In mouse xenograft models, it exhibits strong in vitro anti-proliferative activity and significant in vivo antitumor efficacy.

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