中文版
Signaling Pathways
PT-2385
Catalog No. :
CL2835
Product Name :
PT-2385
CAS No. :
1672665-49-4
Synonyms :
Chemical Name :
Molecular Formula :
C17H12F3NO4S
Molecular Weight :
383.34
Molecular Structure :
Appearance :
White to off-white powder
Specification :
98+%
Application :
Registration :
Storage Condition :

 PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor PT2385 allosterically binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival.

Statement:
->>Products covered by valid patents are not offered or supplied for commercial use.
->>Products currently covered by valid US Patents are offered for laboratory R&D use in accordance with 35 USC 271(e)+A13(1).
->>Any patent infringement and resulting liability is solely at buyer's risk.
->>Our products are only raw materials for drugs or industry, can't be used for human or animals directly.

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