Catalog No. :	CL1003
Product Name :	Y-27632 Dihydrochloride
CAS No. :	129830-38-2
Synonyms :	Y-27632 2HCl;Y 27632 dihydrochloride;Y27632 dihydrochloride
Chemical Name :	trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride
Molecular Formula :	C14H23Cl2N3O
Molecular Weight :	320.26
Molecular Structure :
Appearance :	White to off-white powder
Specification :	98+%
Application :	ROCK inhibitor | Autophagy activator
Registration :
Storage Condition :	4°C, sealed storage, away from moisture

The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM. One-hour treatment with 10 µM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages. 

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