Catalog No. :	CL2817
Product Name :	ZYF0033(HPK1-IN-22)
CAS No. :	2380300-79-6
Synonyms :	HPK1-IN-22
Chemical Name :
Molecular Formula :	C26H30N4O2S
Molecular Weight :	462.61
Molecular Structure :
Appearance :	White to off-white powder
Specification :	98+%
Application :
Registration :
Storage Condition :

HPK1-IN-22 (compound ZYF0033) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 less than 10 nM based on the phosphorylation inhibition of MBP protein. HPK1-IN-22 decreases the phosphorylation of SLP76 (serine 376). HPK1-IN-22 promotes anticancer immune responses.HPK1-IN-22 inhibits tumor growth and caused increases intratumoral infiltration of DCs, NK cells, and CD107a+CD8+ T cells but decreased infiltration of regulatory T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells, and LAG3+CD8+ T cells in the 4T-1 syngeneic mouse model.

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