Catalog No. :	CL3040
Product Name :	Carfilzomib
CAS No. :	868540-17-4
Synonyms :	PR-171
Chemical Name :	(S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide
Molecular Formula :	C40H57N5O7
Molecular Weight :	719.91
Molecular Structure :
Appearance :	White to off-white powder
Specification :	98+%
Application :	Proteasome inhibitor | Autophagy activator | Apoptosis related activator
Registration :
Storage Condition :	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.

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