Catalog No. :	CL2150B
Product Name :	Pemetrexed Disodium Heptahydrate
CAS No. :	357166-29-1
Synonyms :	LY231514 disodium heptahydrate
Chemical Name :	Sodium (S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate heptahydrate.
Molecular Formula :	C20H33N5Na2O13
Molecular Weight :	597.48
Molecular Structure :
Appearance :	White to off-white powder
Specification :	98+%
Application :	Antifolate
Registration :
Storage Condition :	4°C, sealed storage, away from moisture

Pemetrexed disodium heptahydrate (LY231514; HSDB7316; LY-231514; HSDB-7316; Alimta), the heptahydrated disodium salt of Pemetrexed and a pyrimidine-based antifolate, is an antifolate and antimetabolite anticancer medication. It targets TS, DHFR, and GARFT with Ki values of 1.3 nM, 7.2 nM, and 65 nM, in that order. In a variety of tumor types, including malignant mesothelioma, NSCLC (non-small cell lung carcinoma), carcinomas of the breast, colorectum, uterine cervix, head and neck, and bladder, pemetrexed shows strong antitumor activity.

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