Catalog No. :	CL1120A
Product Name :	Tofacitinib Citrate
CAS No. :	540737-29-9
Synonyms :	Tasocitinib Citrate | CP-690550 Citrate
Chemical Name :	1-Piperidinepropanenitrile, 4-methyl-3-(methyl-7H-pyrrolo(2,3-d)pyrimidin-4-ylamino)- beta-oxo-, (3R,4R)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
Molecular Formula :	C16H20N6O.C6H8O7
Molecular Weight :	504.49
Molecular Structure :
Appearance :	White crystalline powder
Specification :	98+%
Application :	rheumatoid arthritis | Janus Kinase Inhibitors
Registration :
Storage Condition :	4°C, sealed storage, away from moisture and light

Tofacitinib, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2). Tofacitinib inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively.

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