Catalog No. :	CL1120
Product Name :	Tofacitinib (CP-690550)
CAS No. :	477600-75-2
Synonyms :	Tasocitinib | CP-690550b
Chemical Name :	3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
Molecular Formula :	C16H20N6O
Molecular Weight :	312.37
Molecular Structure :
Appearance :	White or off-white powder
Specification :	98+%
Application :	rheumatoid arthritis | JAK inhibitor
Registration :
Storage Condition :	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Tofacitinib is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.

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